Version 5.4
Homo sapiens Gene: OGDH
Summary
InnateDB Gene IDBG-15045.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OGDH
Gene Name oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms AKGDH; E1k; OGDC
Species Homo sapiens
Ensembl Gene ENSG00000105953
Encoded Proteins
IDBP-15047
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
IDBP-374291
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
IDBP-374296
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
IDBP-374298
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
IDBP-374299
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
IDBP-374303
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
IDBP-374305
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44606572-44709066
Strand Forward strand
Band p13
Transcripts
ENST00000222673 ENSP00000222673
ENST00000439616 ENSP00000398576
ENST00000443864 ENSP00000388084
ENST00000449767 ENSP00000392878
ENST00000447398 ENSP00000388183
ENST00000419661 ENSP00000411830
ENST00000444676 ENSP00000414662
ENST00000459672
ENST00000497326
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976 thiamine pyrophosphate binding
GO:0031072 heat shock protein binding
GO:0034602 oxoglutarate dehydrogenase (NAD+) activity
GO:0046872 metal ion binding
GO:0051087 chaperone binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006096 glycolytic process
GO:0006099 tricarboxylic acid cycle
GO:0006103 2-oxoglutarate metabolic process
GO:0006104 succinyl-CoA metabolic process
GO:0006554 lysine catabolic process
GO:0006734 NADH metabolic process
GO:0008152 metabolic process
GO:0021695 cerebellar cortex development
GO:0021756 striatum development
GO:0021766 hippocampus development
GO:0021794 thalamus development
GO:0021860 pyramidal neuron development
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
GO:0034641 cellular nitrogen compound metabolic process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0061034 olfactory bulb mitral cell layer development
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0031966 mitochondrial membrane
GO:0045252 oxoglutarate dehydrogenase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020456
View Gene Order
ENSBTAG00000006029
Not yet available
Pathways
NETPATH
REACTOME
REACT_1298
Lysine catabolism pathway
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
hsa00380
Tryptophan metabolism pathway
hsa00310
Lysine degradation pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.488181
RefSeq NM_001003941 NM_001165036 NM_002541
HUGO
OMIM
CCDS CCDS34627 CCDS47580 CCDS55107
HPRD 08938
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca