Version 5.4
Homo sapiens Protein: OGDH
Summary
InnateDB Protein IDBP-374298.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OGDH
Protein Name oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms AKGDH; E1k; OGDC;
Species Homo sapiens
Ensembl Protein ENSP00000392878
InnateDB Gene IDBG-15045 (OGDH)
Protein Structure
UniProt Annotation
Function The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Subcellular Localization Mitochondrion matrix.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976 thiamine pyrophosphate binding
GO:0046872 metal ion binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006096 glycolytic process
GO:0006099 tricarboxylic acid cycle
GO:0006554 lysine catabolic process
GO:0008152 metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID
InterPro IPR001017 Dehydrogenase, E1 component
IPR005475 Transketolase-like, pyrimidine-binding domain
IPR011603 2-oxoglutarate dehydrogenase E1 component
IPR029061 Thiamin diphosphate-binding fold
PFAM PF00676
PF02779
PRINTS
PIRSF PIRSF000157
SMART SM00861
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q02218
PhosphoSite PhosphoSite-Q02218
TrEMBL
UniProt Splice Variant
Entrez Gene 4967
UniGene Hs.488181
RefSeq NP_001158508
HUGO HGNC:8124
OMIM 613022
CCDS CCDS55107
HPRD 08938
IMGT
EMBL AC004859 AC011894 AK304439 BC004964 BC009580 BC014617 CH471128 D10523 D32064
GenPept AAH04964 AAH09580 AAH14617 AAQ96884 AAQ96885 BAA01393 BAA06836 BAG65261 EAW61086 EAW61087 EAW61089

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca