InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OGDH

Summary

InnateDB Protein

IDBP-15047.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OGDH

Protein Name

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

Synonyms

AKGDH; E1k; OGDC;

Species

Homo sapiens

Ensembl Protein

ENSP00000222673

InnateDB Gene

IDBG-15045 (OGDH)

Protein Structure

UniProt Annotation

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976	thiamine pyrophosphate binding
GO:0031072	heat shock protein binding
GO:0034602	oxoglutarate dehydrogenase (NAD+) activity
GO:0046872	metal ion binding
GO:0051087	chaperone binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006096	glycolytic process
GO:0006099	tricarboxylic acid cycle
GO:0006103	2-oxoglutarate metabolic process
GO:0006104	succinyl-CoA metabolic process
GO:0006554	lysine catabolic process
GO:0006734	NADH metabolic process
GO:0008152	metabolic process
GO:0021695	cerebellar cortex development
GO:0021756	striatum development
GO:0021766	hippocampus development
GO:0021794	thalamus development
GO:0021860	pyramidal neuron development
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb
GO:0034641	cellular nitrogen compound metabolic process
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0061034	olfactory bulb mitral cell layer development

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0031966	mitochondrial membrane
GO:0045252	oxoglutarate dehydrogenase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001017 Dehydrogenase, E1 component
IPR005475 Transketolase-like, pyrimidine-binding domain
IPR011603 2-oxoglutarate dehydrogenase E1 component
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF00676
PF02779

PRINTS

PIRSF

PIRSF000157

SMART

SM00861

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt