InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: OGDH

Summary

InnateDB Gene

IDBG-634204.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OGDH

Gene Name

2-oxoglutarate dehydrogenase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006029

Encoded Proteins

IDBP-685978

2-oxoglutarate dehydrogenase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105953:
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:77458516-77512436

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000007922

ENSBTAP00000007922

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0016491	oxidoreductase activity
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976	thiamine pyrophosphate binding
GO:0034602	oxoglutarate dehydrogenase (NAD+) activity
GO:0046872	metal ion binding

Biological Process

GO:0006096	glycolytic process
GO:0006099	tricarboxylic acid cycle
GO:0008152	metabolic process
GO:0021695	cerebellar cortex development
GO:0021756	striatum development
GO:0021766	hippocampus development
GO:0021794	thalamus development
GO:0021860	pyramidal neuron development
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb
GO:0055114	oxidation-reduction process
GO:0061034	olfactory bulb mitral cell layer development