InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OGDH

Summary

InnateDB Protein

IDBP-374296.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OGDH

Protein Name

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

Synonyms

AKGDH; E1k; OGDC;

Species

Homo sapiens

Ensembl Protein

ENSP00000388084

InnateDB Gene

IDBG-15045 (OGDH)

Protein Structure

UniProt Annotation

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976	thiamine pyrophosphate binding
GO:0046872	metal ion binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006096	glycolytic process
GO:0006099	tricarboxylic acid cycle
GO:0006554	lysine catabolic process
GO:0008152	metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process