Homo sapiens Gene: MFNG
Summary
InnateDB Gene IDBG-6573.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFNG
Gene Name MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100060
Encoded Proteins
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37469063-37486401
Strand Reverse strand
Band q13.1
Transcripts
ENST00000356998 ENSP00000349490
ENST00000454291 ENSP00000407094
ENST00000416983 ENSP00000413855
ENST00000438891 ENSP00000414222
ENST00000436341 ENSP00000394081
ENST00000430411 ENSP00000414342
ENST00000442496 ENSP00000389274
ENST00000424765 ENSP00000407110
ENST00000489515
ENST00000466943
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016757 transferase activity, transferring glycosyl groups
GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0007389 pattern specification process
GO:0008152 metabolic process
GO:0032092 positive regulation of protein binding
GO:0045747 positive regulation of Notch signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Notch pathway
REACTOME
Pre-NOTCH Expression and Processing pathway
Signal Transduction pathway
Signaling by NOTCH pathway
Pre-NOTCH Processing in Golgi pathway
KEGG
Other types of O-glycan biosynthesis pathway
Notch signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8WE21
UniProt Splice Variant
Entrez Gene 4242
UniGene Hs.517603 Hs.599316
RefSeq NM_002405 NM_001166343
HUGO HGNC:7038
OMIM 602577
CCDS CCDS13947 CCDS54525
HPRD 03988
IMGT
EMBL Z93096
GenPept
RNA Seq Atlas 4242