Version 5.4
Homo sapiens Protein: MFNG
Summary
InnateDB Protein IDBP-375371.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFNG
Protein Name MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000413855
InnateDB Gene IDBG-6573 (MFNG)
Protein Structure
UniProt Annotation
Function Glycosyltransferase involved in the elongation of O- linked ligands to activate Notch signaling. Possesses fucose- specific beta-1,3-N-acetylglucosaminyltransferase activity. {ECO:0000269PubMed:10935626}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016757 transferase activity, transferring glycosyl groups
GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0007389 pattern specification process
GO:0008152 metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
GO:0030173 integral component of Golgi membrane
Protein Structure and Domains
PDB ID
InterPro IPR003378 Fringe-like
IPR017374 Fringe
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF02434
PRINTS
PIRSF PIRSF038073
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00587
PhosphoSite PhosphoSite-O00587
TrEMBL F6T992
UniProt Splice Variant
Entrez Gene 4242
UniGene Hs.599316
RefSeq NP_001159815
HUGO HGNC:7038
OMIM 602577
CCDS CCDS54525
HPRD 03988
IMGT
EMBL AK297149 AK297833 AK316555 BC094814 CR456518 U94352 Z93096
GenPept AAC51358 AAH94814 BAG59648 BAG60167 BAG65633 CAB07511 CAG30404 CAP58791 CAP58792

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca