Homo sapiens Gene: MFNG | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-6573.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | MFNG | ||||||||||||||||||
Gene Name | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000100060 | ||||||||||||||||||
Encoded Proteins |
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 22:37469063-37486401 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q13.1 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH |
Notch pathway
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REACTOME |
Pre-NOTCH Processing in Golgi pathway
Pre-NOTCH Expression and Processing pathway
Signal Transduction pathway
Signaling by NOTCH pathway
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KEGG |
Notch signaling pathway pathway
Other types of O-glycan biosynthesis pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.517603 Hs.599316 | ||||||||||||||||||
RefSeq | NM_001166343 NM_002405 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS13947 CCDS54525 | ||||||||||||||||||
HPRD | 03988 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||