Mus musculus Gene: Mfng
Summary
InnateDB Gene IDBG-159753.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mfng
Gene Name MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms AW546563;
Species Mus musculus
Ensembl Gene ENSMUSG00000018169
Encoded Proteins
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100060:
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78755882-78773475
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000018313 ENSMUSP00000018313
ENSMUST00000123518
ENSMUST00000136795
ENSMUST00000128389
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016757 transferase activity, transferring glycosyl groups
GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0007389 pattern specification process
GO:0008152 metabolic process
GO:0032092 positive regulation of protein binding
GO:0045747 positive regulation of Notch signaling pathway
Cellular Component
GO:0016020 membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pre-NOTCH Expression and Processing pathway
Pre-NOTCH Processing in Golgi pathway
Signal Transduction pathway
Signaling by NOTCH pathway
KEGG
Other types of O-glycan biosynthesis pathway
Notch signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Notch pathway
REACTOME
Pre-NOTCH Expression and Processing pathway
Signal Transduction pathway
Signaling by NOTCH pathway
Pre-NOTCH Processing in Golgi pathway
KEGG
Other types of O-glycan biosynthesis pathway
Notch signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.149235
RefSeq NM_008595 XM_006520551 XM_006520552
OMIM
CCDS CCDS27622
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas