Bos taurus Gene: MFNG
Summary
InnateDB Gene IDBG-638264.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFNG
Gene Name beta-1,3-N-acetylglucosaminyltransferase manic fringe
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015043
Encoded Proteins
beta-1,3-N-acetylglucosaminyltransferase manic fringe
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100060:
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:76266277-76282792
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020023 ENSBTAP00000020023
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
Biological Process
GO:0007389 pattern specification process
GO:0008152 metabolic process
GO:0032092 positive regulation of protein binding
GO:0045747 positive regulation of Notch signaling pathway
Cellular Component
GO:0016020 membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
Notch pathway
REACTOME
Pre-NOTCH Expression and Processing pathway
Signal Transduction pathway
Signaling by NOTCH pathway
Pre-NOTCH Processing in Golgi pathway
Pre-NOTCH Expression and Processing pathway
Pre-NOTCH Processing in Golgi pathway
Signal Transduction pathway
Signaling by NOTCH pathway
KEGG
Other types of O-glycan biosynthesis pathway
Notch signaling pathway pathway
Other types of O-glycan biosynthesis pathway
Notch signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q1LZD7
UniProt Splice Variant
Entrez Gene 505267
UniGene Bt.13251
RefSeq NM_001101051
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116066 BT030676 DAAA02013848 DAAA02013849 DAAA02013850
GenPept AAI16067 ABS44992
RNA Seq Atlas 505267
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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