Homo sapiens Gene: RASGRP1
Summary
InnateDB Gene IDBG-5885.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASGRP1
Gene Name RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Synonyms CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RASGRP; V;
Species Homo sapiens
Ensembl Gene ENSG00000172575
Encoded Proteins
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:38488103-38565575
Strand Reverse strand
Band q14
Transcripts
ENST00000310803 ENSP00000310244
ENST00000414708 ENSP00000413105
ENST00000450598 ENSP00000388540
ENST00000558432 ENSP00000453583
ENST00000561180 ENSP00000452859
ENST00000559830 ENSP00000452721
ENST00000558164 ENSP00000454164
ENST00000557875 ENSP00000453729
ENST00000560425 ENSP00000454053
ENST00000558418 ENSP00000453905
ENST00000561117 ENSP00000454005
ENST00000560929 ENSP00000452892
ENST00000539159 ENSP00000444762
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0008289 lipid binding
Biological Process
GO:0001816 cytokine production
GO:0002437 inflammatory response to antigenic stimulus
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007596 blood coagulation
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0032252 secretory granule localization
GO:0032856 activation of Ras GTPase activity
GO:0032862 activation of Rho GTPase activity
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043303 mast cell degranulation
GO:0043547 positive regulation of GTPase activity
GO:0045087 innate immune response
GO:0047496 vesicle transport along microtubule
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042629 mast cell granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
Rap1 signalling pathway
FCERI mediated NF-kB activation pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Activation of RAS in B cells pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Integrin alphaIIb beta3 signaling pathway
Adaptive Immune System pathway
Immune System pathway
Effects of PIP2 hydrolysis pathway
Platelet Aggregation (Plug Formation) pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Hemostasis pathway
KEGG
MAPK signaling pathway pathway
T cell receptor signaling pathway pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
PID NCI
TCR signaling in na´ve CD8+ T cells
TCR signaling in na´ve CD4+ T cells
Regulation of Ras family activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591127
RefSeq NM_001128602 NM_005739
HUGO
OMIM
CCDS CCDS45221 CCDS45222
HPRD 04909
IMGT
EMBL
GenPept
RNA Seq Atlas