InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RASGRP1

Summary

InnateDB Gene

IDBG-5885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGRP1

Gene Name

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

Synonyms

CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RASGRP; V

Species

Homo sapiens

Ensembl Gene

ENSG00000172575

Encoded Proteins

IDBP-5887

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-365353

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-365364

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-589614

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-583645

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-600996

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-585126

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-589656

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-591536

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-584997

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-588804

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-583996

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

IDBP-603810

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:38488103-38565575

Strand

Reverse strand

Band

q14

Transcripts

ENST00000310803	ENSP00000310244
ENST00000414708	ENSP00000413105
ENST00000450598	ENSP00000388540
ENST00000558432	ENSP00000453583
ENST00000561180	ENSP00000452859
ENST00000559830	ENSP00000452721
ENST00000558164	ENSP00000454164
ENST00000557875	ENSP00000453729
ENST00000560425	ENSP00000454053
ENST00000558418	ENSP00000453905
ENST00000561117	ENSP00000454005
ENST00000560929	ENSP00000452892
ENST00000539159	ENSP00000444762

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0008289	lipid binding

Biological Process

GO:0001816	cytokine production
GO:0002437	inflammatory response to antigenic stimulus
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0007596	blood coagulation
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
GO:0030154	cell differentiation
GO:0030168	platelet activation
GO:0032252	secretory granule localization
GO:0032856	activation of Ras GTPase activity
GO:0032862	activation of Rho GTPase activity
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043303	mast cell degranulation
GO:0043547	positive regulation of GTPase activity
GO:0045087	innate immune response
GO:0047496	vesicle transport along microtubule
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0042629	mast cell granule