InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASGRP1

Summary

InnateDB Protein

IDBP-365353.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGRP1

Protein Name

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

Synonyms

CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RASGRP; V;

Species

Homo sapiens

Ensembl Protein

ENSP00000413105

InnateDB Gene

IDBG-5885 (RASGRP1)

Protein Structure

UniProt Annotation

Function

Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation. {ECO:0000269PubMed:10807788, ECO:0000269PubMed:12782630, ECO:0000269PubMed:12839994, ECO:0000269PubMed:12845332, ECO:0000269PubMed:15060167, ECO:0000269PubMed:15184873, ECO:0000269PubMed:15899849}.

Subcellular Localization

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity). {ECO:0000250}.

Disease Associations

Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269PubMed:17878389}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.

Tissue Specificity

Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). {ECO:0000269PubMed:10807788, ECO:0000269PubMed:17878389, ECO:0000269PubMed:9789079}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0008289	lipid binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0007596	blood coagulation
GO:0030154	cell differentiation
GO:0030168	platelet activation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR002048 EF-hand domain
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00618
PF00617
PF00036
PF13202
PF13405

PRINTS

PIRSF

SMART

SM00229
SM00147
SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95267