InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rasgrp1

Summary

InnateDB Gene

IDBG-197782.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasgrp1

Gene Name

RAS guanyl releasing protein 1

Synonyms

Rasgrp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027347

Encoded Proteins

IDBP-197784

RAS guanyl releasing protein 1

IDBP-626326

RAS guanyl releasing protein 1

IDBP-626329

RAS guanyl releasing protein 1

IDBP-626332

RAS guanyl releasing protein 1

IDBP-626335

RAS guanyl releasing protein 1

IDBP-718824

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172575:
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:117279993-117343001

Strand

Reverse strand

Band

Transcripts

ENSMUST00000102534	ENSMUSP00000099593
ENSMUST00000110898
ENSMUST00000174770	ENSMUSP00000134167
ENSMUST00000173541	ENSMUSP00000134027
ENSMUST00000172901	ENSMUSP00000133449
ENSMUST00000173252	ENSMUSP00000134592
ENSMUST00000178884	ENSMUSP00000136423

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding

Biological Process

GO:0001816	cytokine production
GO:0002437	inflammatory response to antigenic stimulus
GO:0007264	small GTPase mediated signal transduction
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
GO:0030154	cell differentiation
GO:0032252	secretory granule localization
GO:0032856	activation of Ras GTPase activity
GO:0032862	activation of Rho GTPase activity
GO:0035556	intracellular signal transduction
GO:0043303	mast cell degranulation
GO:0047496	vesicle transport along microtubule
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0042629	mast cell granule