Version 5.4
Mus musculus Protein: Rasgrp1
Summary
InnateDB Protein IDBP-626332.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rasgrp1
Protein Name RAS guanyl releasing protein 1
Synonyms Rasgrp;
Species Mus musculus
Ensembl Protein ENSMUSP00000133449
InnateDB Gene IDBG-197782 (Rasgrp1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
Biological Process
GO:0001816 cytokine production
GO:0002437 inflammatory response to antigenic stimulus
GO:0007264 small GTPase mediated signal transduction
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0032252 secretory granule localization
GO:0032856 activation of Ras GTPase activity
GO:0032862 activation of Rho GTPase activity
GO:0035556 intracellular signal transduction
GO:0043303 mast cell degranulation
GO:0047496 vesicle transport along microtubule
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0042629 mast cell granule
Protein Structure and Domains
PDB ID MGI:1314635
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR020454 Diacylglycerol/phorbol-ester binding
IPR023578 Ras guanine nucleotide exchange factor, domain
PFAM PF00618
PF00617
PF00036
PF13202
PF13405
PF00130
PRINTS PR00008
PIRSF
SMART SM00229
SM00147
SM00054
SM00109
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3UWW4
UniProt Splice Variant
Entrez Gene 19419
UniGene Mm.42150
RefSeq
MGI ID
MGI Symbol Rasgrp1
OMIM
CCDS
HPRD
IMGT
EMBL AL844579 AL928959
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca