Homo sapiens Gene: MINK1
Summary
InnateDB Gene IDBG-19945.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MINK1
Gene Name misshapen-like kinase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141503
Encoded Proteins
misshapen-like kinase 1
misshapen-like kinase 1
misshapen-like kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:4833388-4898061
Strand Forward strand
Band p13.2
Transcripts
ENST00000347992 ENSP00000269296
ENST00000355280 ENSP00000347427
ENST00000453408 ENSP00000406487
ENST00000575511
ENST00000571207 ENSP00000459699
ENST00000572330
ENST00000571526
ENST00000576037 ENSP00000459102
ENST00000574871
ENST00000572304
ENST00000577021 ENSP00000459269
ENST00000574453 ENSP00000461500
ENST00000572629
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001952 regulation of cell-matrix adhesion
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0007254 JNK cascade
GO:0007268 synaptic transmission
GO:0007275 multicellular organismal development
GO:0022407 regulation of cell-cell adhesion
GO:0030334 regulation of cell migration
GO:0031532 actin cytoskeleton reorganization
GO:0035556 intracellular signal transduction
GO:0045060 negative thymic T cell selection
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048813 dendrite morphogenesis
GO:0050790 regulation of catalytic activity
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0045211 postsynaptic membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Cellular responses to stress pathway
Cellular Senescence pathway
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.443417
RefSeq NM_001024937 NM_015716 NM_153827 NM_170663 XM_005256665 XM_005256666 XM_006721534
HUGO
OMIM
CCDS CCDS45588 CCDS45589 CCDS45590
HPRD 11366
IMGT
EMBL
GenPept
RNA Seq Atlas