Version 5.4
Mus musculus Gene: Mink1
Summary
InnateDB Gene IDBG-194763.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mink1
Gene Name misshapen-like kinase 1 (zebrafish)
Synonyms B55; Map4k6; MINK; Ysk2
Species Mus musculus
Ensembl Gene ENSMUSG00000020827
Encoded Proteins
IDBP-194765
misshapen-like kinase 1 (zebrafish)
IDBP-194767
misshapen-like kinase 1 (zebrafish)
IDBP-194769
misshapen-like kinase 1 (zebrafish)
IDBP-194771
misshapen-like kinase 1 (zebrafish)
IDBP-194773
misshapen-like kinase 1 (zebrafish)
IDBP-535530
misshapen-like kinase 1 (zebrafish)
IDBP-717980
IDBP-718478
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141503:
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:70562881-70614483
Strand Forward strand
Band B3
Transcripts
ENSMUST00000072237 ENSMUSP00000072091
ENSMUST00000102559 ENSMUSP00000099619
ENSMUST00000102558 ENSMUSP00000099618
ENSMUST00000079244 ENSMUSP00000078234
ENSMUST00000072873 ENSMUSP00000072649
ENSMUST00000133310
ENSMUST00000136663 ENSMUSP00000117959
ENSMUST00000149845 ENSMUSP00000137075
ENSMUST00000153503
ENSMUST00000152857
ENSMUST00000142650
ENSMUST00000132208
ENSMUST00000178764 ENSMUSP00000136149
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001952 regulation of cell-matrix adhesion
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0007268 synaptic transmission
GO:0007275 multicellular organismal development
GO:0022407 regulation of cell-cell adhesion
GO:0023014 signal transduction by phosphorylation
GO:0030334 regulation of cell migration
GO:0031532 actin cytoskeleton reorganization
GO:0035556 intracellular signal transduction
GO:0045060 negative thymic T cell selection
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048813 dendrite morphogenesis
GO:0050790 regulation of catalytic activity
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0045211 postsynaptic membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141503
View Gene Order
ENSBTAG00000004907
Not yet available
Pathways
NETPATH
REACTOME
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_188957
Cellular responses to stress pathway
REACT_188820
Cellular Senescence pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.42967
RefSeq NM_001045959 NM_001045964 NM_016713 NM_176893 XM_006533681 XM_006537176
OMIM
CCDS CCDS24954 CCDS24955 CCDS36205 CCDS48837
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca