InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mink1

Summary

InnateDB Protein

IDBP-194767.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mink1

Protein Name

misshapen-like kinase 1 (zebrafish)

Synonyms

B55; Map4k6; MINK; Ysk2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099619

InnateDB Gene

IDBG-194763 (Mink1)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. {ECO:0000269PubMed:10708748, ECO:0000269PubMed:15608642}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.

Disease Associations

Tissue Specificity

Appears to be ubiquitous, expressed in all tissue types examined. Highly expressed in the brain, moderately expressed in kidney and spleen, low levels present in heart and skeletal muscle. Isoform 2 is more abundant in the brain than isoform 1. {ECO:0000269PubMed:10708748}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0007268	synaptic transmission
GO:0007275	multicellular organismal development
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction
GO:0045060	negative thymic T cell selection
GO:0046777	protein autophosphorylation
GO:0048813	dendrite morphogenesis
GO:0050790	regulation of catalytic activity
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Cellular Component

GO:0005737	cytoplasm
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1355329

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt