Version 5.4
Bos taurus Gene: MINK1
Summary
InnateDB Gene IDBG-634249.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MINK1
Gene Name misshapen-like kinase 1
Synonyms MINK
Species Bos taurus
Ensembl Gene ENSBTAG00000004907
Encoded Proteins
IDBP-686032
misshapen-like kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141503:
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:27123625-27170653
Strand Reverse strand
Band
Transcripts
ENSBTAT00000017318 ENSBTAP00000017318
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001952 regulation of cell-matrix adhesion
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0022407 regulation of cell-cell adhesion
GO:0023014 signal transduction by phosphorylation
GO:0030334 regulation of cell migration
GO:0031532 actin cytoskeleton reorganization
GO:0045060 negative thymic T cell selection
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000141503
View Gene Order
ENSMUSG00000020827
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_188957
Cellular responses to stress pathway
REACT_188820
Cellular Senescence pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A6H7I9 F6Q3P6 Q8MJX6
UniProt Splice Variant
Entrez Gene 519558
UniGene Bt.54709
RefSeq NM_001099376
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB070520 BC146263 DAAA02048753
GenPept AAI46264 BAB97297
RNA Seq Atlas 519558

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca