InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MINK1

Summary

InnateDB Protein

IDBP-19947.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MINK1

Protein Name

misshapen-like kinase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000269296

InnateDB Gene

IDBG-19945 (MINK1)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15469942, ECO:0000269PubMed:18930710}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.Isoform 4: Golgi apparatus.

Disease Associations

Tissue Specificity

Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis. {ECO:0000269PubMed:15469942}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001952	regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0007254	JNK cascade
GO:0007268	synaptic transmission
GO:0007275	multicellular organismal development
GO:0022407	regulation of cell-cell adhesion
GO:0030334	regulation of cell migration
GO:0031532	actin cytoskeleton reorganization
GO:0035556	intracellular signal transduction
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0048813	dendrite morphogenesis
GO:0050790	regulation of catalytic activity
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt