Version 5.4
Homo sapiens Gene: EEF2
Summary
InnateDB Gene IDBG-18151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EEF2
Gene Name eukaryotic translation elongation factor 2
Synonyms EEF-2; EF-2; EF2; SCA26
Species Homo sapiens
Ensembl Gene ENSG00000167658
Encoded Proteins
IDBP-18153
eukaryotic translation elongation factor 2
IDBP-759964
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3976056-3985469
Strand Reverse strand
Band p13.3
Transcripts
ENST00000309311 ENSP00000307940
ENST00000594885
ENST00000600720
ENST00000600794 ENSP00000471265
ENST00000596417
ENST00000598182
ENST00000598436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 137 [view]
Protein-Protein 137 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008494 translation activator activity
GO:0019901 protein kinase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006412 translation
GO:0006414 translational elongation
GO:0008219 cell death
GO:0010467 gene expression
GO:0010628 positive regulation of gene expression
GO:0044267 cellular protein metabolic process
GO:0045727 positive regulation of translation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005844 polysome
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034994
View Gene Order
ENSBTAG00000004258
Not yet available
Pathways
NETPATH
REACTOME
REACT_1404
Peptide chain elongation pathway
REACT_1477
Eukaryotic Translation Elongation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515070
RefSeq NM_001961
HUGO
OMIM
CCDS CCDS12117
HPRD 00561
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca