InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EEF2

Summary

InnateDB Protein

IDBP-18153.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EEF2

Protein Name

eukaryotic translation elongation factor 2

Synonyms

EEF-2; EF-2; EF2; SCA26;

Species

Homo sapiens

Ensembl Protein

ENSP00000307940

InnateDB Gene

IDBG-18151 (EEF2)

Protein Structure

UniProt Annotation

Function

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

Subcellular Localization

Cytoplasm.

Disease Associations

Spinocerebellar ataxia 26 (SCA26) [MIM:609306]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. {ECO:0000269PubMed:23001565}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	137 [view]
Protein-Protein	137 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008494	translation activator activity
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006412	translation
GO:0006414	translational elongation
GO:0008219	cell death
GO:0010467	gene expression
GO:0010628	positive regulation of gene expression
GO:0044267	cellular protein metabolic process
GO:0045727	positive regulation of translation

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005844	polysome
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000640 Translation elongation factor EFG, V domain
IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR005225 Small GTP-binding protein domain
IPR005517 Translation elongation factor EFG/EF2, domain IV
IPR009000 Translation protein, beta-barrel domain
IPR009022 Elongation factor G, III-V domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00679
PF00009
PF03144
PF03764
PF14492

PRINTS

PR00315

PIRSF

SMART

SM00838
SM00889

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt