Version 5.4
Mus musculus Gene: Eef2
Summary
InnateDB Gene IDBG-177168.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eef2
Gene Name eukaryotic translation elongation factor 2
Synonyms Ef-2
Species Mus musculus
Ensembl Gene ENSMUSG00000034994
Encoded Proteins
IDBP-177170
eukaryotic translation elongation factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167658:
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81176631-81182507
Strand Forward strand
Band C1
Transcripts
ENSMUST00000047864 ENSMUSP00000046101
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 92 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008494 translation activator activity
GO:0019901 protein kinase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006184 GTP catabolic process
GO:0006414 translational elongation
GO:0010628 positive regulation of gene expression
GO:0045727 positive regulation of translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167658
View Gene Order
ENSBTAG00000004258
Not yet available
Pathways
NETPATH
REACTOME
REACT_253640
Peptide chain elongation pathway
REACT_254308
Translation pathway
REACT_247926
Metabolism of proteins pathway
REACT_232254
Eukaryotic Translation Elongation pathway
REACT_233572
Gene Expression pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1404
Peptide chain elongation pathway
REACT_1477
Eukaryotic Translation Elongation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
REACT_202833
Peptide chain elongation pathway
REACT_226022
Gene Expression pathway
REACT_209048
Translation pathway
REACT_213782
Metabolism of proteins pathway
REACT_225811
Eukaryotic Translation Elongation pathway
KEGG
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
Cross-References
SwissProt P58252
TrEMBL Q3TPG2 Q3TSK4 Q99LT6
UniProt Splice Variant
Entrez Gene 13629
UniGene Mm.326799 Mm.383798 Mm.402403 Mm.412818
RefSeq NM_007907
OMIM
CCDS CCDS35993
HPRD
IMGT
MGI ID MGI:95288
MGI Symbol Eef2
EMBL AK040474 AK077866 AK087985 AK145545 AK146947 AK151487 AK151812 AK151945 AK152146 AK152447 AK152587 AK152826 AK153275 AK155325 AK159806 AK161993 AK163063 AK164406 AK166212 AK166596 AK166747 AK166751 AK166851 AK166968 AK167093 AK167109 AK167115 AK167221 AK168794 AK168827 AK168874 AK169013 BC002233 BC007152
GenPept AAH02233 AAH07152 BAC30601 BAC37041 BAC40076 BAE26498 BAE27556 BAE30440 BAE30710 BAE30820 BAE30983 BAE31226 BAE31336 BAE31527 BAE31861 BAE33192 BAE35386 BAE36671 BAE37177 BAE37774 BAE38631 BAE38882 BAE38989 BAE38992 BAE39070 BAE39151 BAE39249 BAE39257 BAE39263 BAE39346 BAE40627 BAE40654 BAE40692 BAE40810
RNA Seq Atlas 13629

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca