Mus musculus Protein: Eef2 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-177170.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Eef2 | ||||||||||||||||||||||
Protein Name | eukaryotic translation elongation factor 2 | ||||||||||||||||||||||
Synonyms | Ef-2; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000046101 | ||||||||||||||||||||||
InnateDB Gene | IDBG-177168 (Eef2) | ||||||||||||||||||||||
Protein Structure |
![]() |
||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:95288 | ||||||||||||||||||||||
InterPro |
IPR000640
Translation elongation factor EFG, V domain IPR000795 Elongation factor, GTP-binding domain IPR004161 Translation elongation factor EFTu/EF1A, domain 2 IPR005225 Small GTP-binding protein domain IPR005517 Translation elongation factor EFG/EF2, domain IV IPR009000 Translation protein, beta-barrel domain IPR009022 Elongation factor G, III-V domain IPR020568 Ribosomal protein S5 domain 2-type fold IPR027417 P-loop containing nucleoside triphosphate hydrolase |
||||||||||||||||||||||
PFAM |
PF00679
PF00009 PF03144 PF03764 PF14492 |
||||||||||||||||||||||
PRINTS |
PR00315
|
||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00838
SM00889 |
||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P58252 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P58252 | ||||||||||||||||||||||
TrEMBL | Q99LT6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 13629 | ||||||||||||||||||||||
UniGene | Mm.412818 | ||||||||||||||||||||||
RefSeq | NP_031933 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Eef2 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS35993 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK040474 AK077866 AK087985 AK145545 AK146947 AK151487 AK151812 AK151945 AK152146 AK152447 AK152587 AK152826 AK153275 AK155325 AK159806 AK161993 AK163063 AK164406 AK166212 AK166596 AK166747 AK166751 AK166851 AK166968 AK167093 AK167109 AK167115 AK167221 AK168794 AK168827 AK168874 AK169013 BC002233 BC007152 | ||||||||||||||||||||||
GenPept | AAH02233 AAH07152 BAC30601 BAC37041 BAC40076 BAE26498 BAE27556 BAE30440 BAE30710 BAE30820 BAE30983 BAE31226 BAE31336 BAE31527 BAE31861 BAE33192 BAE35386 BAE36671 BAE37177 BAE37774 BAE38631 BAE38882 BAE38989 BAE38992 BAE39070 BAE39151 BAE39249 BAE39257 BAE39263 BAE39346 BAE40627 BAE40654 BAE40692 BAE40810 | ||||||||||||||||||||||