Homo sapiens Gene: ARID4A
Summary
InnateDB Gene IDBG-7785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARID4A
Gene Name AT rich interactive domain 4A (RBP1-like)
Synonyms RBBP-1; RBBP1; RBP-1; RBP1;
Species Homo sapiens
Ensembl Gene ENSG00000032219
Encoded Proteins
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:58298385-58373887
Strand Forward strand
Band q23.1
Transcripts
ENST00000355431 ENSP00000347602
ENST00000348476 ENSP00000344556
ENST00000395168 ENSP00000378597
ENST00000431317 ENSP00000397368
ENST00000431612 ENSP00000410417
ENST00000445108 ENSP00000392567
ENST00000424658 ENSP00000415872
ENST00000417477 ENSP00000416053
ENST00000469635
ENST00000466065
ENST00000553355
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 26 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006366 transcription from RNA polymerase II promoter
GO:0034773 histone H4-K20 trimethylation
GO:0036124 histone H3-K9 trimethylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048821 erythrocyte development
GO:0080182 histone H3-K4 trimethylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HDACs deacetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8WAR5
UniProt Splice Variant
Entrez Gene 5926
UniGene Hs.161000
RefSeq NM_002892 NM_023000 NM_023001
HUGO HGNC:9885
OMIM 180201
CCDS CCDS9732 CCDS45114 CCDS9733
HPRD 01575
IMGT
EMBL AL132989 AL139021
GenPept
RNA Seq Atlas 5926