Version 5.4
Mus musculus Gene: Arid4a
Summary
InnateDB Gene IDBG-146330.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arid4a
Gene Name AT rich interactive domain 4A (RBP1-like)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000048118
Encoded Proteins
IDBP-146332
AT rich interactive domain 4A (RBP1-like)
IDBP-536190
AT rich interactive domain 4A (RBP1-like)
IDBP-537604
AT rich interactive domain 4A (RBP1-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000032219:
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:71015990-71098592
Strand Forward strand
Band C2
Transcripts
ENSMUST00000046305 ENSMUSP00000035512
ENSMUST00000134718
ENSMUST00000125125 ENSMUSP00000121109
ENSMUST00000135709 ENSMUSP00000121319
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0034773 histone H4-K20 trimethylation
GO:0036124 histone H3-K9 trimethylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048821 erythrocyte development
GO:0080182 histone H3-K4 trimethylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000032219
View Gene Order
ENSBTAG00000018898
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228222
HDACs deacetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.241601
RefSeq NM_001081195 XM_006515833
OMIM
CCDS CCDS36471
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca