InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARID4A

Summary

InnateDB Protein

IDBP-7787.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARID4A

Protein Name

AT rich interactive domain 4A (RBP1-like)

Synonyms

RBBP-1; RBBP1; RBP-1; RBP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000347602

InnateDB Gene

IDBG-7785 (ARID4A)

Protein Structure

UniProt Annotation

Function

Interacts with the viral protein-binding domain of the retinoblastoma protein.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00355, ECO:0000269PubMed:8455946}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	26 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0006349	regulation of gene expression by genetic imprinting
GO:0006366	transcription from RNA polymerase II promoter
GO:0034773	histone H4-K20 trimethylation
GO:0036124	histone H3-K9 trimethylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048821	erythrocyte development
GO:0080182	histone H3-K4 trimethylation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0017053	transcriptional repressor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000953 Chromo domain/shadow
IPR001606 ARID/BRIGHT DNA-binding domain
IPR002999 Tudor domain
IPR012603 RBB1NT
IPR016197 Chromo domain-like
IPR025995 RNA binding activity-knot of a chromodomain

PFAM

PF01388
PF00567
PF08169
PF11717

PRINTS

PIRSF

SMART

SM00298
SM00501
SM00333

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29374