Version 5.4
Homo sapiens Gene: EPHA5
Summary
InnateDB Gene IDBG-20887.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPHA5
Gene Name EPH receptor A5
Synonyms CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4
Species Homo sapiens
Ensembl Gene ENSG00000145242
Encoded Proteins
IDBP-20889
EPH receptor A5
IDBP-20891
EPH receptor A5
IDBP-368943
EPH receptor A5
IDBP-477213
EPH receptor A5
IDBP-813653
EPH receptor A5
IDBP-813654
EPH receptor A5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:65319563-65670495
Strand Reverse strand
Band q13.2
Transcripts
ENST00000273854 ENSP00000273854
ENST00000354839 ENSP00000346899
ENST00000432638 ENSP00000389208
ENST00000511294 ENSP00000427638
ENST00000613740 ENSP00000478537
ENST00000622150 ENSP00000480763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411 axon guidance
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019933 cAMP-mediated signaling
GO:0021766 hippocampus development
GO:0032314 regulation of Rac GTPase activity
GO:0032793 positive regulation of CREB transcription factor activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0048013 ephrin receptor signaling pathway
GO:0048666 neuron development
GO:0051964 negative regulation of synapse assembly
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
GO:0005791 rough endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029245
View Gene Order
ENSBTAG00000009438
Not yet available
Pathways
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
ephrinarevpathway
Ephrin A reverse signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001281765 NM_001281766 NM_001281767 NM_004439 NM_182472
HUGO
OMIM
CCDS CCDS3513 CCDS3514 CCDS75131 CCDS75132 CCDS75133
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca