InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPHA5

Summary

InnateDB Protein

IDBP-20891.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA5

Protein Name

EPH receptor A5

Synonyms

CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4;

Species

Homo sapiens

Ensembl Protein

ENSP00000346899

InnateDB Gene

IDBG-20887 (EPHA5)

Protein Structure

UniProt Annotation

Function

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000269PubMed:10375373, ECO:0000269PubMed:9191074}.

Disease Associations

Tissue Specificity

Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord. {ECO:0000269PubMed:10375373, ECO:0000269PubMed:9191074}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019933	cAMP-mediated signaling
GO:0021766	hippocampus development
GO:0032314	regulation of Rac GTPase activity
GO:0032793	positive regulation of CREB transcription factor activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0048013	ephrin receptor signaling pathway
GO:0048666	neuron development
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus

Cellular Component

GO:0005791	rough endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1

PFAM