Homo sapiens Gene: CLDN3
Summary
InnateDB Gene IDBG-20433.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN3
Gene Name claudin 3
Synonyms C7orf1; CPE-R2; CPETR2; HRVP1; RVP1;
Species Homo sapiens
Ensembl Gene ENSG00000165215
Encoded Proteins
claudin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:73768997-73770270
Strand Reverse strand
Band q11.23
Transcripts
ENST00000395145 ENSP00000378577
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0007165 signal transduction
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016328 lateral plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Tight junction interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
Hepatitis C pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O15551
TrEMBL Q75L79
UniProt Splice Variant
Entrez Gene 1365
UniGene Hs.647023
RefSeq NM_001306
HUGO HGNC:2045
OMIM 602910
CCDS CCDS5559
HPRD
IMGT
EMBL AB000714 AC093168 AF007189 AK313276 BC016056 CH471200
GenPept AAC78277 AAH16056 AAS07555 BAA22986 BAG36084 EAW69641
RNA Seq Atlas 1365