Version 5.4
Mus musculus Gene: Cldn3
Summary
InnateDB Gene IDBG-203329.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cldn3
Gene Name claudin 3
Synonyms AI182374; Cpetr2; mRVP1
Species Mus musculus
Ensembl Gene ENSMUSG00000070473
Encoded Proteins
IDBP-203331
claudin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a low-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein is highly overexpressed in uterine carcinosarcoma. This protein is also predominantly present in brain endothelial cells, where it plays a specific role in the establishment and maintenance of blood brain barrier tight junction morphology. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:134986214-134987472
Strand Forward strand
Band G2
Transcripts
ENSMUST00000094245 ENSMUSP00000091799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016328 lateral plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165215
View Gene Order
ENSBTAG00000040432
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04530
Tight junction pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu05160
Hepatitis C pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
REACT_214866
Cell junction organization pathway
REACT_206475
Cell-Cell communication pathway
REACT_207240
Cell-cell junction organization pathway
REACT_216942
Tight junction interactions pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt Q9Z0G9
TrEMBL Q3TMQ3 Q545A5
UniProt Splice Variant
Entrez Gene 12739
UniGene Mm.489604
RefSeq NM_009902
OMIM
CCDS CCDS19729
HPRD
IMGT
MGI ID MGI:1329044
MGI Symbol Cldn3
EMBL AF087821 AF095905 AK002672 AK012677 AK165808 BC012650 CH466529
GenPept AAD09756 AAD14608 AAH12650 BAB22275 BAB28403 BAE38388 EDL19402
RNA Seq Atlas 12739

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca