Version 5.4
Mus musculus Protein: Cldn3
Summary
InnateDB Protein IDBP-203331.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cldn3
Protein Name claudin 3
Synonyms AI182374; Cpetr2; mRVP1;
Species Mus musculus
Ensembl Protein ENSMUSP00000091799
InnateDB Gene IDBG-203329 (Cldn3)
Protein Structure
UniProt Annotation
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000269PubMed:10508613}.
Subcellular Localization Cell junction, tight junction {ECO:0000269PubMed:9892664}. Cell membrane {ECO:0000269PubMed:9892664}; Multi-pass membrane protein {ECO:0000269PubMed:9892664}.
Disease Associations
Tissue Specificity Expressed at high levels in liver and lung and, at lower levels, in kidney and testis. {ECO:0000269PubMed:9892664}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016328 lateral plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1329044
InterPro IPR003549 Claudin-3
IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR006187 Claudin
PFAM PF00822
PF13903
PRINTS PR01378
PR01077
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z0G9
PhosphoSite PhosphoSite-Q9Z0G9
TrEMBL Q545A5
UniProt Splice Variant
Entrez Gene 12739
UniGene Mm.489604
RefSeq NP_034032
MGI ID
MGI Symbol Cldn3
OMIM
CCDS CCDS19729
HPRD
IMGT
EMBL AF087821 AF095905 AK002672 AK012677 AK165808 BC012650 CH466529
GenPept AAD09756 AAD14608 AAH12650 BAB22275 BAB28403 BAE38388 EDL19402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca