Homo sapiens Gene: RANBP1
Summary
InnateDB Gene IDBG-1621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RANBP1
Gene Name RAN binding protein 1
Synonyms HTF9A;
Species Homo sapiens
Ensembl Gene ENSG00000099901
Encoded Proteins
RAN binding protein 1
RAN binding protein 1
RAN binding protein 1
RAN binding protein 1
RAN binding protein 1
RAN binding protein 1
RAN binding protein 1
RAN binding protein 1
RAN binding protein 1
RAN binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN. [provided by RefSeq, Jul 2008]
This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:20115938-20127357
Strand Forward strand
Band q11.21
Transcripts
ENST00000331821 ENSP00000327583
ENST00000402752 ENSP00000384925
ENST00000435265 ENSP00000390139
ENST00000432879 ENSP00000404724
ENST00000430524 ENSP00000401564
ENST00000411892 ENSP00000395472
ENST00000416427 ENSP00000404126
ENST00000421656 ENSP00000400940
ENST00000423859 ENSP00000404298
ENST00000418705 ENSP00000413502
ENST00000448394
ENST00000488484
ENST00000467920
ENST00000486575
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005092 GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
GO:0008536 Ran GTPase binding
Biological Process
GO:0007051 spindle organization
GO:0007165 signal transduction
GO:0016032 viral process
GO:0043547 positive regulation of GTPase activity
GO:0046604 positive regulation of mitotic centrosome separation
GO:0046907 intracellular transport
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Late Phase of HIV Life Cycle pathway
HIV Life Cycle pathway
Rev-mediated nuclear export of HIV RNA pathway
HIV Infection pathway
Host Interactions of HIV factors pathway
Interactions of Rev with host cellular proteins pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
Role of ran in mitotic spindle regulation [Biocarta view]
Mechanism of protein import into the nucleus [Biocarta view]
Cycling of ran in nucleocytoplasmic transport [Biocarta view]
PID NCI
E2F transcription factor network
Cross-References
SwissProt
TrEMBL C9JDM3
UniProt Splice Variant
Entrez Gene 5902
UniGene Hs.24763
RefSeq NM_001278639 NM_001278640 NM_001278641 NM_002882 XM_006724288
HUGO HGNC:9847
OMIM 601180
CCDS CCDS13775 CCDS63408 CCDS74823
HPRD 03110
IMGT
EMBL AC006547
GenPept
RNA Seq Atlas 5902