Mus musculus Gene: Ranbp1
Summary
InnateDB Gene IDBG-141228.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ranbp1
Gene Name RAN binding protein 1
Synonyms Htf9a;
Species Mus musculus
Ensembl Gene ENSMUSG00000005732
Encoded Proteins
RAN binding protein 1
RAN binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099901:
Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN. [provided by RefSeq, Jul 2008]
This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:18239784-18248732
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000052325 ENSMUSP00000055288
ENSMUST00000115645 ENSMUSP00000111309
ENSMUST00000123073
ENSMUST00000134035
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0007051 spindle organization
GO:0043547 positive regulation of GTPase activity
GO:0046604 positive regulation of mitotic centrosome separation
GO:0046907 intracellular transport
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Late Phase of HIV Life Cycle pathway
HIV Life Cycle pathway
Rev-mediated nuclear export of HIV RNA pathway
HIV Infection pathway
Host Interactions of HIV factors pathway
Interactions of Rev with host cellular proteins pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
Role of ran in mitotic spindle regulation [Biocarta view]
Mechanism of protein import into the nucleus [Biocarta view]
Cycling of ran in nucleocytoplasmic transport [Biocarta view]
PID NCI
E2F transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.235287 Mm.367034
RefSeq NM_011239
OMIM
CCDS CCDS37280
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas