InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ranbp1

Summary

InnateDB Gene

IDBG-141228.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ranbp1

Gene Name

RAN binding protein 1

Synonyms

Htf9a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005732

Encoded Proteins

IDBP-141230

RAN binding protein 1

IDBP-249179

RAN binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099901:
Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN. [provided by RefSeq, Jul 2008]
This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:18239784-18248732

Strand

Reverse strand

Band

Transcripts

ENSMUST00000052325	ENSMUSP00000055288
ENSMUST00000115645	ENSMUSP00000111309
ENSMUST00000123073
ENSMUST00000134035

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0007051	spindle organization
GO:0043547	positive regulation of GTPase activity
GO:0046604	positive regulation of mitotic centrosome separation
GO:0046907	intracellular transport