Homo sapiens Gene: CDH6
Summary
InnateDB Gene IDBG-14130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH6
Gene Name cadherin 6, type 2, K-cadherin (fetal kidney)
Synonyms CAD6; KCAD;
Species Homo sapiens
Ensembl Gene ENSG00000113361
Encoded Proteins
cadherin 6, type 2, K-cadherin (fetal kidney)
cadherin 6, type 2, K-cadherin (fetal kidney)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:31193750-31329146
Strand Forward strand
Band p13.3
Transcripts
ENST00000265071 ENSP00000265071
ENST00000514738 ENSP00000424843
ENST00000506396
ENST00000508132
ENST00000504835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
Adherens junctions interactions pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6RF86
UniProt Splice Variant
Entrez Gene 1004
UniGene Hs.124776 Hs.171054 Hs.627403 Hs.669314
RefSeq NM_004932
HUGO HGNC:1765
OMIM 603007
CCDS CCDS3894
HPRD 04305
IMGT
EMBL AC091898 AC113386
GenPept
RNA Seq Atlas 1004