Version 5.4
Homo sapiens Gene: CDH6
Summary
InnateDB Gene IDBG-14130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH6
Gene Name cadherin 6, type 2, K-cadherin (fetal kidney)
Synonyms CAD6; KCAD
Species Homo sapiens
Ensembl Gene ENSG00000113361
Encoded Proteins
IDBP-14132
cadherin 6, type 2, K-cadherin (fetal kidney)
IDBP-474632
cadherin 6, type 2, K-cadherin (fetal kidney)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:31193750-31329146
Strand Forward strand
Band p13.3
Transcripts
ENST00000265071 ENSP00000265071
ENST00000514738 ENSP00000424843
ENST00000506396
ENST00000508132
ENST00000504835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039385
View Gene Order
ENSBTAG00000012992
Not yet available
Pathways
NETPATH
REACTOME
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P55285
TrEMBL D6RF86
UniProt Splice Variant
Entrez Gene 1004
UniGene Hs.124776 Hs.171054 Hs.627403 Hs.669314
RefSeq NM_004932
HUGO HGNC:1765
OMIM 603007
CCDS CCDS3894
HPRD
IMGT
EMBL AC091898 AC113386 AK291290 BC000019 CH471118 D31784
GenPept AAH00019 BAA06562 BAF83979 EAX10764
RNA Seq Atlas 1004

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca