Version 5.4
Homo sapiens Gene: CNN2
Summary
InnateDB Gene IDBG-13604.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNN2
Gene Name calponin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000064666
Encoded Proteins
IDBP-13606
calponin 2
IDBP-13608
calponin 2
IDBP-761796
IDBP-761190
IDBP-808245
calponin 2
IDBP-766110
IDBP-808233
calponin 2
IDBP-760364
IDBP-764135
IDBP-808242
calponin 2
IDBP-808243
calponin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1026581-1039068
Strand Forward strand
Band p13.3
Transcripts
ENST00000263097 ENSP00000263097
ENST00000348419 ENSP00000340129
ENST00000562075 ENSP00000455777
ENST00000562958 ENSP00000456436
ENST00000564572
ENST00000566695 ENSP00000484533
ENST00000569352 ENSP00000468577
ENST00000562015 ENSP00000479188
ENST00000568865 ENSP00000458137
ENST00000565096 ENSP00000457968
ENST00000606983 ENSP00000484749
ENST00000607102 ENSP00000475175
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0010628 positive regulation of gene expression
GO:0030097 hemopoiesis
GO:0030336 negative regulation of cell migration
GO:0031032 actomyosin structure organization
GO:0032970 regulation of actin filament-based process
GO:0042060 wound healing
GO:0042127 regulation of cell proliferation
GO:0050765 negative regulation of phagocytosis
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0001725 stress fiber
GO:0005856 cytoskeleton
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004665
View Gene Order
ENSBTAG00000020764
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.624503 Hs.651512 Hs.723390
RefSeq NM_004368 NM_201277
HUGO
OMIM
CCDS CCDS12053 CCDS12054
HPRD 03847
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca