InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNN2

Summary

InnateDB Protein

IDBP-13606.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNN2

Protein Name

calponin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263097

InnateDB Gene

IDBG-13604 (CNN2)

Protein Structure

UniProt Annotation

Function

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

Subcellular Localization

Disease Associations

Tissue Specificity

Heart and smooth muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0010628	positive regulation of gene expression
GO:0030097	hemopoiesis
GO:0030336	negative regulation of cell migration
GO:0031032	actomyosin structure organization
GO:0032970	regulation of actin filament-based process
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0050765	negative regulation of phagocytosis
GO:0071260	cellular response to mechanical stimulus