Homo sapiens Gene: AKAP3
Summary
InnateDB Gene IDBG-13126.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP3
Gene Name A kinase (PRKA) anchor protein 3
Synonyms AKAP 110; AKAP110; CT82; FSP95; HEL159; PRKA3; SOB1;
Species Homo sapiens
Ensembl Gene ENSG00000111254
Encoded Proteins
A kinase (PRKA) anchor protein 3
A kinase (PRKA) anchor protein 3
A kinase (PRKA) anchor protein 3
A kinase (PRKA) anchor protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. [provided by RefSeq, Jul 2008]
This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:4615508-4649047
Strand Reverse strand
Band p13.32
Transcripts
ENST00000228850 ENSP00000228850
ENST00000545990 ENSP00000440994
ENST00000540967 ENSP00000442376
ENST00000536414 ENSP00000439382
ENST00000541484
ENST00000544636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051018 protein kinase A binding
Biological Process
GO:0006928 cellular component movement
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007338 single fertilization
GO:0007340 acrosome reaction
GO:0008104 protein localization
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0031514 motile cilium
GO:0035686 sperm fibrous sheath
GO:0097228 sperm principal piece
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.98397
RefSeq NM_001278309 NM_006422 XM_005253664 XM_006718951
HUGO
OMIM
CCDS CCDS8531
HPRD 05256
IMGT
EMBL
GenPept
RNA Seq Atlas