InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKAP3

Summary

InnateDB Protein

IDBP-13128.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP3

Protein Name

A kinase (PRKA) anchor protein 3

Synonyms

AKAP 110; AKAP110; CT82; FSP95; HEL159; PRKA3; SOB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000228850

InnateDB Gene

IDBG-13126 (AKAP3)

Protein Structure

UniProt Annotation

Function

May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.

Disease Associations

Tissue Specificity

Testis specific; only expressed in spermatids.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051018	protein kinase A binding

Biological Process

GO:0006928	cellular component movement
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007338	single fertilization
GO:0007340	acrosome reaction
GO:0008104	protein localization