InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AKAP3

Summary

InnateDB Gene

IDBG-13126.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP3

Gene Name

A kinase (PRKA) anchor protein 3

Synonyms

AKAP 110; AKAP110; CT82; FSP95; HEL159; PRKA3; SOB1

Species

Homo sapiens

Ensembl Gene

ENSG00000111254

Encoded Proteins

IDBP-13128

A kinase (PRKA) anchor protein 3

IDBP-586672

A kinase (PRKA) anchor protein 3

IDBP-585375

A kinase (PRKA) anchor protein 3

IDBP-597896

A kinase (PRKA) anchor protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. [provided by RefSeq, Jul 2008]
This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:4615508-4649047

Strand

Reverse strand

Band

p13.32

Transcripts

ENST00000228850	ENSP00000228850
ENST00000545990	ENSP00000440994
ENST00000540967	ENSP00000442376
ENST00000536414	ENSP00000439382
ENST00000541484
ENST00000544636

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051018	protein kinase A binding

Biological Process

GO:0006928	cellular component movement
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007338	single fertilization
GO:0007340	acrosome reaction
GO:0008104	protein localization

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005634	nucleus
GO:0031514	motile cilium
GO:0035686	sperm fibrous sheath
GO:0097228	sperm principal piece

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030344

View Gene Order

ENSBTAG00000001020

Not yet available

Cross-References

SwissProt

TrEMBL

F5H2S4

UniProt Splice Variant

Entrez Gene

10566

UniGene

Hs.98397

RefSeq

NM_001278309 NM_006422 XM_005253664 XM_006718951

HUGO

HGNC:373

OMIM

604689

CCDS

CCDS8531

HPRD

05256

IMGT

EMBL

AC005832

GenPept

RNA Seq Atlas

10566