Bos taurus Gene: AKAP3
Summary
InnateDB Gene IDBG-640668.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP3
Gene Name A-kinase anchor protein 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001020
Encoded Proteins
A-kinase anchor protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111254:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. [provided by RefSeq, Jul 2008]
This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:105896016-105941353
Strand Forward strand
Band
Transcripts
ENSBTAT00000001353 ENSBTAP00000001353
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051018 protein kinase A binding
Biological Process
GO:0006928 cellular component movement
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0008104 protein localization
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0031514 motile cilium
GO:0035686 sperm fibrous sheath
GO:0097228 sperm principal piece
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.219
RefSeq NM_001101039 XM_005207172 XM_005207173
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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