Homo sapiens Gene: C12orf5
Summary
InnateDB Gene IDBG-12954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C12orf5
Gene Name chromosome 12 open reading frame 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000078237
Encoded Proteins
chromosome 12 open reading frame 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:4321205-4354593
Strand Forward strand
Band p13.32
Transcripts
ENST00000179259 ENSP00000179259
ENST00000539671
ENST00000537251
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
Biological Process
GO:0009410 response to xenobiotic stimulus
GO:0010332 response to gamma radiation
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016311 dephosphorylation
GO:0060576 intestinal epithelial cell development
GO:1901525 negative regulation of macromitophagy
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Fructose and mannose metabolism pathway
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.504545 Hs.598023
RefSeq NM_020375
HUGO
OMIM
CCDS CCDS8525
HPRD 12610
IMGT
EMBL
GenPept
RNA Seq Atlas