Version 5.4
Bos taurus Gene: TIGAR
Summary
InnateDB Gene IDBG-640708.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIGAR
Gene Name Fructose-2,6-bisphosphatase TIGAR
Synonyms TIGAR
Species Bos taurus
Ensembl Gene ENSBTAG00000016650
Encoded Proteins
IDBP-692996
Probable fructose-2,6-bisphosphatase TIGAR
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078237:
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:106223071-106238040
Strand Reverse strand
Band
Transcripts
ENSBTAT00000022146 ENSBTAP00000022146
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0010332 response to gamma radiation
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016311 dephosphorylation
GO:0060576 intestinal epithelial cell development
GO:1901525 negative regulation of macromitophagy
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000078237
View Gene Order
ENSMUSG00000038028
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00051
Fructose and mannose metabolism pathway
mmu00051
Fructose and mannose metabolism pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.61374
RefSeq NM_001076370 XM_005207193
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca