Version 5.4
Bos taurus Protein: TIGAR
Summary
InnateDB Protein IDBP-692996.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIGAR
Protein Name Probable fructose-2,6-bisphosphatase TIGAR
Synonyms TIGAR;
Species Bos taurus
Ensembl Protein ENSBTAP00000022146
InnateDB Gene IDBG-640708 (TIGAR)
Protein Structure
UniProt Annotation
Function Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0010332 response to gamma radiation
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016311 dephosphorylation
GO:0060576 intestinal epithelial cell development
GO:1901525 negative regulation of macromitophagy
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR013078 Histidine phosphatase superfamily, clade-1
IPR029033 Histidine phosphatase superfamily
PFAM PF00300
PRINTS
PIRSF
SMART SM00855
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1JQA7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 615392
UniGene Bt.61374
RefSeq NP_001069838
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116101
GenPept AAI16102

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca