InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C12orf5

Summary

InnateDB Protein

IDBP-12956.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C12orf5

Protein Name

chromosome 12 open reading frame 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000179259

InnateDB Gene

IDBG-12954 (C12orf5)

Protein Structure

UniProt Annotation

Function

Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53. {ECO:0000269PubMed:16839880}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity

Biological Process

GO:0009410	response to xenobiotic stimulus
GO:0010332	response to gamma radiation
GO:0010666	positive regulation of cardiac muscle cell apoptotic process
GO:0016311	dephosphorylation
GO:0060576	intestinal epithelial cell development
GO:1901525	negative regulation of macromitophagy
GO:2000378	negative regulation of reactive oxygen species metabolic process