Version 5.4
Homo sapiens Gene: SLC9A3
Summary
InnateDB Gene IDBG-10338.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC9A3
Gene Name solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Synonyms NHE3
Species Homo sapiens
Ensembl Gene ENSG00000066230
Encoded Proteins
IDBP-10340
solute carrier family 9 (sodium/hydrogen exchanger), member 3
IDBP-482365
solute carrier family 9 (sodium/hydrogen exchanger), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:473310-524332
Strand Reverse strand
Band p15.33
Transcripts
ENST00000264938 ENSP00000264938
ENST00000514375 ENSP00000422983
ENST00000507407
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015299 solute:proton antiporter activity
GO:0015385 sodium:proton antiporter activity
GO:0030165 PDZ domain binding
Biological Process
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0006885 regulation of pH
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0031988 membrane-bounded vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036123
View Gene Order
ENSBTAG00000004629
Not yet available
Pathways
NETPATH
REACTOME
REACT_19314
Sodium/Proton exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04964
Proximal tubule bicarbonate reclamation pathway
hsa04976
Bile secretion pathway
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
endothelinpathway
Endothelins
rhoa_pathway
RhoA signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.658120
RefSeq NM_001284351 NM_004174
HUGO
OMIM
CCDS CCDS3855 CCDS64116
HPRD 01660
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca