Homo sapiens Gene: SLC9A3
Summary
InnateDB Gene IDBG-10338.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC9A3
Gene Name solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Synonyms NHE3;
Species Homo sapiens
Ensembl Gene ENSG00000066230
Encoded Proteins
solute carrier family 9 (sodium/hydrogen exchanger), member 3
solute carrier family 9 (sodium/hydrogen exchanger), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:473310-524332
Strand Reverse strand
Band p15.33
Transcripts
ENST00000264938 ENSP00000264938
ENST00000514375 ENSP00000422983
ENST00000507407
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015299 solute:proton antiporter activity
GO:0015385 sodium:proton antiporter activity
GO:0030165 PDZ domain binding
Biological Process
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0006885 regulation of pH
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0031988 membrane-bounded vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Sodium/Proton exchangers pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
SLC-mediated transmembrane transport pathway
KEGG
Proximal tubule bicarbonate reclamation pathway
Protein digestion and absorption pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Endothelins
RhoA signaling pathway
Cross-References
SwissProt P48764
TrEMBL
UniProt Splice Variant
Entrez Gene 6550
UniGene Hs.658120
RefSeq NM_004174 NM_001284351
HUGO HGNC:11073
OMIM 182307
CCDS CCDS3855 CCDS64116
HPRD 01660
IMGT
EMBL AC010442 AC106772 BC101669 BC101671 BC143328 U28043
GenPept AAB48990 AAI01670 AAI01672 AAI43329
RNA Seq Atlas 6550