InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC9A3

Summary

InnateDB Protein

IDBP-10340.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC9A3

Protein Name

solute carrier family 9 (sodium/hydrogen exchanger), member 3

Synonyms

NHE3;

Species

Homo sapiens

Ensembl Protein

ENSP00000264938

InnateDB Gene

IDBG-10338 (SLC9A3)

Protein Structure

UniProt Annotation

Function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:19088451}; Multi-pass membrane protein {ECO:0000269PubMed:19088451}. Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015299	solute:proton antiporter activity
GO:0015385	sodium:proton antiporter activity
GO:0030165	PDZ domain binding

Biological Process

GO:0006811	ion transport
GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0006885	regulation of pH
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005903	brush border
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0031988	membrane-bounded vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004709 Na+/H+ exchanger
IPR006153 Cation/H+ exchanger
IPR011256 Regulatory factor, effector binding domain
IPR018410 Na+/H+ exchanger, isoforms 3/5

PFAM

PF00999

PRINTS

PR01084
PR01087

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48764