InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC9A3

Summary

InnateDB Protein

IDBP-482365.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC9A3

Protein Name

solute carrier family 9 (sodium/hydrogen exchanger), member 3

Synonyms

NHE3;

Species

Homo sapiens

Ensembl Protein

ENSP00000422983

InnateDB Gene

IDBG-10338 (SLC9A3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015299	solute:proton antiporter activity
GO:0015385	sodium:proton antiporter activity
GO:0030165	PDZ domain binding

Biological Process

GO:0006811	ion transport
GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0006885	regulation of pH
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005903	brush border
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004709 Na+/H+ exchanger
IPR006153 Cation/H+ exchanger
IPR011256 Regulatory factor, effector binding domain
IPR018410 Na+/H+ exchanger, isoforms 3/5

PFAM

PF00999

PRINTS

PR01084
PR01087

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48764