InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTLA4

Summary

InnateDB Gene

IDBG-79215.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTLA4

Gene Name

cytotoxic T-lymphocyte-associated protein 4

Synonyms

CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12

Species

Homo sapiens

Ensembl Gene

ENSG00000163599

Encoded Proteins

IDBP-79217

cytotoxic T-lymphocyte-associated protein 4

IDBP-79219

cytotoxic T-lymphocyte-associated protein 4

IDBP-388515

cytotoxic T-lymphocyte-associated protein 4

IDBP-476155

cytotoxic T-lymphocyte-associated protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18824539

CTLA4 blockade abrogates protection by regulatory T cells in a mouse model of microbe-induced innate immune-driven colitis.

Entrez Gene

Summary

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:203867786-203873960

Strand

Forward strand

Band

q33.2

Transcripts

ENST00000302823	ENSP00000303939
ENST00000295854	ENSP00000295854
ENST00000427473	ENSP00000409707
ENST00000487393
ENST00000472206	ENSP00000417779

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0006974	cellular response to DNA damage stimulus
GO:0030889	negative regulation of B cell proliferation
GO:0031295	T cell costimulation
GO:0042130	negative regulation of T cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045590	negative regulation of regulatory T cell differentiation
GO:0050777	negative regulation of immune response
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0045334	clathrin-coated endocytic vesicle
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026011

View Gene Order

ENSBTAG00000013170

Not yet available

Pathways

NETPATH

NetPath_11

TCR pathway

REACTOME

REACT_19405

CTLA4 inhibitory signaling pathway

REACT_19344

Costimulation by the CD28 family pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04660

T cell receptor signaling pathway pathway

hsa05320

Autoimmune thyroid disease pathway

INOH

PID NCI

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.247824

RefSeq

NM_001037631 NM_005214

HUGO

OMIM

CCDS

CCDS2362 CCDS42803

HPRD

00474

IMGT

EMBL

GenPept

RNA Seq Atlas