InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ctla4

Summary

InnateDB Gene

IDBG-159662.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctla4

Gene Name

cytotoxic T-lymphocyte-associated protein 4

Synonyms

Cd152; Ctla-4; Ly-56

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026011

Encoded Proteins

IDBP-159664

cytotoxic T-lymphocyte-associated protein 4

IDBP-159666

cytotoxic T-lymphocyte-associated protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18824539

[Homo sapiens] CTLA4 blockade abrogates protection by regulatory T cells in a mouse model of microbe-induced innate immune-driven colitis.

Entrez Gene

Summary

This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:60887000-60915832

Strand

Forward strand

Band

Transcripts

ENSMUST00000027164	ENSMUSP00000027164
ENSMUST00000097720	ENSMUSP00000095327
ENSMUST00000124816

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	9 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0006974	cellular response to DNA damage stimulus
GO:0030889	negative regulation of B cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0045590	negative regulation of regulatory T cell differentiation
GO:0050777	negative regulation of immune response
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005794	Golgi apparatus
GO:0009897	external side of plasma membrane
GO:0045334	clathrin-coated endocytic vesicle
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000163599

View Gene Order

ENSBTAG00000013170

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04514

Cell adhesion molecules (CAMs) pathway

mmu04660

T cell receptor signaling pathway pathway

mmu05320

Autoimmune thyroid disease pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

REACT_19405

CTLA4 inhibitory signaling pathway

REACT_19344

Costimulation by the CD28 family pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04660

T cell receptor signaling pathway pathway

hsa05320

Autoimmune thyroid disease pathway

INOH

PID NCI

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Cross-References

SwissProt

TrEMBL

Q5SSM0 Q9Z1A8

UniProt Splice Variant

Entrez Gene

12477

UniGene

Mm.390

RefSeq

NM_001281976 NM_009843

OMIM

CCDS

CCDS69893 CCDS14993

HPRD

IMGT

MGI ID

MGI:88556

MGI Symbol

Ctla4

EMBL

AL646054 AL663047 CR936839 U90270

GenPept

AAD00696 CAM13244

RNA Seq Atlas

12477