InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTLA4

Summary

InnateDB Protein

IDBP-79219.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTLA4

Protein Name

cytotoxic T-lymphocyte-associated protein 4

Synonyms

CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12;

Species

Homo sapiens

Ensembl Protein

ENSP00000295854

InnateDB Gene

IDBG-79215 (CTLA4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0006974	cellular response to DNA damage stimulus
GO:0030889	negative regulation of B cell proliferation
GO:0031295	T cell costimulation
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045590	negative regulation of regulatory T cell differentiation
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0045334	clathrin-coated endocytic vesicle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR008096 Cytotoxic T-lymphocyte antigen 4
IPR013106 Immunoglobulin V-set domain

PFAM

PF07686

PRINTS

PR01720

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt